Acquired Inhibitor of Factor VIII
Presenting as Delayed
Wound Healing
Published: June 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/21598.10109
Sushma Nayar, Kishore Babu Esakkimuthu Parvathi, Mayilananthi Kaliannan, Premlatha Sivasailam
1. Associate Professor, Department of Pathology, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
2. Assistant Professor, Department of Surgery, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
3. Associate Professor, Department of Medicine, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
4. Professor, Department of Surgery, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai, Kelambakkam, Kanchipuram, Chennai, Tamil Nadu, India.
Correspondence
Dr. Sushma Nayar,
Associate Professor, Department of Pathology, Chettinad Hospital and Research Institute, Rajiv Gandhi Salai,
Kelambakkam, Kanchipuram District, Chennai-603103, Tamil Nadu, India.
E-mail: divya_s35@hotmail.com
Acquired coagulation factor VIII inhibitor leads to a rare disease i.e., acquired haemophilia which is idiopathic in majority of cases and is seen with autoimmune diseases, haematologic and solid tumours, infections, in the post-partum period and also with certain long-term use of drugs like penicillin and its derivatives, phenytoin, sulfa antibiotics, chloramphenicol, methyldopa, chlorpromazine, levodopa, interferon-a, fludarabine, clopidogrel. We report a case here, with acquired Factor VIII (FVIII) inhibitor acquisition which presented with delayed wound healing as a result of protracted bleeding into the wound. The inhibitor was acquired due to prolonged chlorpromazine use.
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